Research 1 | Human Mini-brain Modeling
Our lab focuses on human minibrain modeling using advanced microfluidic chip platforms that integrate key components of the neurovascular and gut-brain systems. By incorporating human-derived brain cells into these microenvironments, we aim to replicate critical features of the brain, including neuronal signaling, the blood-brain barrier (BBB), cerebrovascular function, and gut-brain axis communication. This approach allows us to study neurodegenerative disease mechanisms and therapeutic responses in a controlled, human-relevant system. Through these models, we investigate how the interaction between brain cells, endothelial barriers, and peripheral signals contribute to brain health and pathology.
Blood-Brain-Barrier Chip
Neuron-glia Chip
Neuronal Circuit Chip
Research 2 | Neuromodulation
Our lab studies neurodegenerative diseases and dementia by investigating cellular signals using microfluidic chips, which help us understand disease mechanisms and explore potential treatments. Building on this platform, we also explore neuromodulation strategies—such as electrical stimulation, optogenetics, and biochemical cues—to regulate neuronal activity and glial responses. By integrating these approaches into our minibrain models, we aim to uncover how targeted modulation can influence disease progression and promote functional recovery in neurodegenerative conditions.
Research 3 | Aging
Our lab investigates the mechanisms of brain aging by modeling cellular interactions and dynamics using advanced microfluidic platforms. These systems allow us to recreate age-associated changes in neuronal function, glial reactivity, and neurovascular coupling under precisely controlled conditions. Building on this platform, we explore how age-related stressors—such as mitochondrial dysfunction, impaired waste clearance, and chronic inflammation—reshape neural homeostasis. Furthermore, we integrate neuromodulation strategies including electrical stimulation, optogenetic control, and biochemical cues to restore network balance and rejuvenate aged neural circuits. Through this approach, we aim to uncover how targeted modulation of neuronal and glial signaling can decelerate neurodegenerative progression and promote resilience in the aging brain.