Research 1 | Human Mini-brain Modeling

Our lab focuses on human minibrain modeling using advanced microfluidic chip platforms that integrate key components of the neurovascular and gut-brain systems. By incorporating human-derived brain cells into these microenvironments, we aim to replicate critical features of the brain, including neuronal signaling, the blood-brain barrier (BBB), cerebrovascular function, and gut-brain axis communication. This approach allows us to study neurodegenerative disease mechanisms and therapeutic responses in a controlled, human-relevant system. Through these models, we investigate how the interaction between brain cells, endothelial barriers, and peripheral signals contribute to brain health and pathology.

Neuroglia Chip

Neuronal Circuit Chip

Blood-Brain-Barrier Chip

Research 2 | Neuromodulation

Our lab studies neurodegenerative diseases and dementia by investigating cellular signals using microfluidic chips, which help us understand disease mechanisms and explore potential treatments. Building on this platform, we also explore neuromodulation strategies—such as electrical stimulation, optogenetics, and biochemical cues—to regulate neuronal activity and glial responses. By integrating these approaches into our minibrain models, we aim to uncover how targeted modulation can influence disease progression and promote functional recovery in neurodegenerative conditions.

Neuron-Glial Interaction

Research 3 | Quantum Biology

Our lab explores quantum biology using microfluidic brain models to investigate how quantum phenomena—such as tunneling, coherence, and entanglement—may play a role in neural signaling and brain function. By applying these models to neurodegenerative disease research, we aim to uncover whether disruptions in quantum-level processes contribute to cognitive decline and impaired cellular communication.