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Journal Articles and Conference Proceedings


For most updated list, click here: Google Scholar


2024

59. H. Kim, E. Lee, M. Park, K. Min, Y.N. Diep, J. Kim, H. Ahn, E. Lee, S. Kim, Y. Kim, Y.J. Kang, J.H. Jung, M. S. Byun, Y. Joo, C. Jeong, D.Y. Lee, H. Cho, H. Park, T. Kim, “Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation,” Brain Behavior and Immunity, 2024, 122:568

58. J.-C. Park, J.W. Han, W. Lee, J. Kim, S.-E. Lee, D. Lee, H. Choi, J. Han, Y.J. Kang, Y.N. Diep, H. Cho, J.-I. Kim, I. Mook-Jung, “Microglia gravitate toward amyloid plaques surrounded by externalized phosphatidylserine via TREM2,” Advanced Science, 2024, 11:2400064

57. Y.J. Kang, S.J. Hyeon, A. McQuade, J. Lim, S.H. Baek, Y.N. Diep, K.V. Do, Y Jeon, D.-G. Jo, C.J. Lee, M. Blurton-Jones, H. Ryu, H. Cho, “Neurotoxic microglial activation via IFNγ-induced Nrf2 reduction exacerbating Alzheimer’s disease,” Advanced Sciences, 2024, 12:2304357

56. G. Ambrin, Y.J Kang, K.V. Do, C. Lee, B.R. Singh, H. Cho, “Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflammatory Responses,” Advance Sciences, 2024, 11:2305326

55. Y. Xue, M. Tran, S. Shin, J. Lee, H. Cho*, Y.J. Kang*, “Environmental Aluminum Oxide Inducing Neurodegeneration in Human Neurovascular Unit with Immunity,” Scientific Reports, 2024, 14:744


- M. Tran, H. Cho, “Microengineered Blood-Choroid Plexus System for Studying Neurodegenerative Disease,” Microphysiological systems (MPS) World Submit, June 10-14, 2024, Seattle, WA, USA (oral presentation)

- V.T.A. Tran, L.P. Lee, H. Cho, “Escherichia coli K1 meningitis induces H3K4me3 trimethylation-mediating neurotoxic synucleinopathy in a gut-brain axis microphysiological system,” the Society for Neuroscience’s 52nd annual meeting (Neuroscience 2024), Chicago, Il, USA, Oct. 5-9, 2024

- K.V. Do, M. Tran, Y.J. Kang, T. Huynh, C. Heo, H. Cho, “Chronic Glucocorticoids xbstructing Astrocytic Neuroprotection via NIX-Mitophagy,” the Society for Neuroscience’s 52nd annual meeting (Neuroscience 2024), Chicago, Il, USA, Oct. 5-9, 2024

- M. Tran, Chaeyeon Been1-3, Hansang Cho, “Human gut-blood-brain axis microarchitecture model for two-way gut-neuropathogenesis studies,” MicroTAS 2024, Montréal, Canada, Oct. 13-17, 2024 (oral presentation)

- Minh Tran, Do Hyun Nam, Luke P. Lee, Hansang Cho. “Blood-Choroid Plexus Microphysiological System for Studying Neurodegenerative Diseases” 2023 Nature Conference: Bioengineering for Global Health, Vanderbilt University, Nashville, TN, USA, November 13-15, 2023.

- Minh Tran, Luke P. Lee, Hansang Cho. “Microengineered Blood-choroid plexus system for studying neurodegenerative disease. ” 2023 MPS world submit 2024, June 9-14,2024 in Seattle, WA, USA 

   (oral presentation).

- Y.N. Diep, X. Zhu, H. Cho, “Glioblastoma-neuroimmune Platform for Proinflammatory Glia Transformation Via Glutamate/C3 Activity,” 7th Tissue Engineering and Regenerative Medicine World Congress 2024 (TERMIS-WC 2024), June 25-28, 2024, Seattle, WA, USA (oral presentation)

- A. Jamsranjav, H. Park, D. Lee, H. Cho, “Neuro Proteino-pathy induced by Polystyrene nano plastic via NLRP-3 Activation in Glial Cells,” International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders (AD/PD 2024), Lisbon, Portugal, March 5-9, 2024

- K.V. Do, M. Tran, Y.J. Kang, C. Been, H. Cho, “BNIP3L/NIX-Mediated Mitophagy Impairment in Glucocorticoid-Enriched Alzheimer's Diseased Brains,” International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders (AD/PD 2024), Lisbon, Portugal, March 5-9, 2024

- V.T.A. Tran, M. Song, S.G. Hong, Y.N. Diep, L.P. Lee, H. Cho, “Hepatic Copper Overload Inducing Tauopathy and Synucleinopathy via Overexpression of Mitochondrial Lipoyltransferase 1 in Neurodegenerative Liver-Brain Axis,” International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders (AD/PD 2024), Lisbon, Portugal, March 5-9, 2024




2023

54. M. Bae*, H. Ngo*, Y.J. Kang, S.-J. Lee, W. Park, Y. Jo, Y.-M. Choi, J.J. Kim, H.-G. Yi, H.-S. Kim*, J. Jang*, D.-W. Cho*, H. Cho*, “Laminin-Augmented Decellularized Extracellular Matrix Ameliorating Neural Differentiation and Neuroinflammation in Human Mini-Brains,” Small, 2023, 19: 2308815

53. J. Choi, S. Seo, S. Lee, H. Ko, Y. Luo, Y. Han, J.H. Shin, H. Cho, H. Lee, “Low-Temperature Layer-by-Layer Growth of Semiconducting Few-Layer Graphyne to Exploit Robust Biocompatibility,” ACS Applied Materials & Interfaces 2023, 15:41708

52. T. Badloe, Y. Kim, J. Kim, H. Park, A. Barulin, Y. Diep, H. Cho, W-S Kim, Y-K Kim, I. Kim, J. Rho, “Bright-Field and Edge-Enhanced Imaging Using an Electrically Tunable Dual-Mode Metalens,” ACS Nano 2023, 17:14678

51. Y.J. Kang, Y.N. Diep, M. Tran, V.T.A Tran, G. Ambrin, H. Ngo, H. Cho*, “Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration,” Nature Protocols 2023, 18:9 (cover imaged)

50. Y.N. Diep, H.J. Park, J.-H. Kwon, M. Tran, H.Y. Ko, H. Jo, J. Kim, J.-I. Chung, T.Y. Kim, D. Kim, J.H. Chang, Y.J. Kang, C.J. Lee, M. Yun, H. Cho*, “Astrocytic Scar Restricting Glioblastoma via Glutamate–MAO-B Activity in Glioblastoma-Microglia Assembloid,” Biomaterials Research 2023, 27:71

49. H. Ngo, S. Amartumur, V.T.A. Tran, M. Tran, Y. Diep, H. Cho*, L.P. Lee* (*:co-corresponding), “In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening,” Biosensors 2023, 13:231

48. Y.J. Kang, Y. Xue, J.H. Shin, H. Cho, “Human mini-brains for reconstituting CNS disorders,” Lab on a Chip 2023, 23:964


- Y.N. Diep, H. Cho, “A 3D Human Glial Scar-Barrier-on-a-Chip for Assessing Reduced Drug Sensitivity to Scar-Glioblastoma,” MicroTAS, Katowice, Poland, Oct. 15 – 19, 2023

- Y.N. Diep, H.J. Park, J.-H. Kwon, M. Tran, H.Y. Ko, H. Jo, J. Kim, J.-I. Chung, T.Y. Kim, M. Yun, C.J. Lee, and H. Cho, “Astrocytic Scar Restricting Glioblastoma via Glutamate–MAO-B Activity in Glioblastoma-Microglia Assembloid,” Keystone Symposia, British Columbia, CA, May 15-19, 2023

- M. Tran, Y.J. Kang, Y.N. Diep, K.V. Do, H. Cho, “Hyperammonemia-induced autophagy impairment and tauopathy mediated with MAO-A in 3D human edema mini-brain,” Keystone Symposia, British Columbia, CA, May 15-19, 2023

- H. Ngo, Y. Diep, H. Cho, “SARS-COV2 spike protein triggers neuroinflammation and antiviral responses mediated by Toll-like receptors 2/4 in a human mini-brain,” International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders (AD/PD 2023), Gothenburg, Sweden, March 28- April 1, 2023




2022

47. M. Tran, C. Heo, L.P. Lee, H. Cho, “Human mini-blood-brain barrier models for biomedical neuroscience research: a review,” Biomaterials Research 2022, 26:82

46. M.-H. Hwang, Y.-J. Kang, H.-G. Son, H. Cho*, Hyuk Choi* (*:co-corresponding), “Engineered Human Intervertebral Disc Model Inducing Degenerative,” International Journal of Molecular Science 2022, 23:12216

45. Y.N. Diep, T.J. Kim*, H. Cho*, L.P. Lee* (*:co-corresponding), “Nanomedicine for Advanced Cancer Immunotherapy,” Journal of Controlled Release 2022, 351:1017

44. Y.G. Lee, H. Cho, S.S. Park “High-throughput screening of anti-cancer drugs using a microfluidic spheroid culture device with a concentration gradient generator,” Current Protocols 2022, 2:e529

43. V.T.A. Tran, L.P. Lee, H. Cho, “Neuroinflammation in neurodegeneration via microbial infections,” Frontiers in Immunology 2022, 13:907804

42. J.H. Shin, S. Park, H. Cho, J.H. Kim, H. Choi “Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation,” Scientific Reports 2022, 12:8936

41. V.A. Jairaman, A. McQuade, A. Granzotto, Y.J. Kang, J.P. Chadarevian, S. Gandhi, I. Parker, I. Smith, H. Cho, S.L. Sensi, S. Othy, M. Blurton-Jones, M.D. Cahalan “TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia,” eLife 2022, 11:e73021

40. Y. Lee, S. Ahn, H. Cho, V. Ogunro, S. Bae “Solventless solid-phase extraction using Zn ion-imprinted polymer detected by colorimetric method,” Bulletin of the Korean Chemical Society 2022, 43:429


- H. Cho, “Human Mini-Brains for Neurological Disorders,” Asian Congress for Alternatives to Animal Experiments 2022 (ACAAE 2022), Jeju, Korea, Dec. 15, 2022

- Y.J. Kang, S.J. Hyeon, A. McQuade, J. Lim, S.H. Baek, D.-G. Jo, C.J. Lee, M. Blurton-Jones, H. Ryu, H. Cho, “IFNg-driven Nrf2 downregulation in microglia exacerbates Alzheimer’s disease,” the Society for  

Neuroscience’s 50th annual meeting (Neuroscience 2022), San Diego, CA, USA, Nov. 12-16, 2022

- J.H. Shin, H. Cho, “Resistin and glucose stimulation promotes proinflammatory astro-microgliosis in human obesity hyperglycemia,” the Society for Neuroscience’s 50th annual meeting (Neuroscience 2022), San Diego, CA, USA, Nov. 12-16, 2022

- M. Tran, Y.J. Kang, H. Cho, “Hyperammonemia-derived glutamine storm promoting MAO-A mediated tauopathy in human edema mini-brain,”the Society for Neuroscience’s 50th annual meeting (Neuroscience 2022), San Diego, CA, USA, Nov. 12-16, 2022

- V.T.A. Tran, H. Cho, “Helicobacter pylori’s cell-free supernatant (HPCFS) induces neurodegenerative neuroinflammation in human mini-brain,”the Society for Neuroscience’s 50th annual meeting (Neuroscience 2022), San Diego, CA, USA, Nov. 12-16, 2022

- H. Ngo, M. Bae, Y.J. Kang, J. Jang, D.-W. Cho, H. Cho, “Construction of Physiological Cerebral Environment Augmented with a Brain Decellularized Extracellular Matrix – Matrigel Hybrid,” the Society for - Neuroscience’s 50th annual meeting (Neuroscience 2022), San Diego, CA, USA, Nov. 12-16, 2022

- Y.N. Diep, H.Y. Ko, T.Y. Kim, C.J. Lee, M. Yun, H. Cho, “Glutamate-inducing MAO-B as a Critical Modulator for the Astrocytic Scar in a Human Glioblastoma Microenvironment Organoid and Xenograft Mouse Model,” Tissue Engineering and Regenerative Medicine-Asia Pacific 2022 (TERMIS-AP 2022), Jeju, Korea, Oct. 5-8, 2022 (Best Poster Presentation Award)

- Y.J. Kang, H.-Y. Tan, C.Y. Lee, H. Cho, “Fine particulate matter in air pollutants promotes neuroinflammation and exacerbates tauopathy in human minibrain,” 2022 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders (AD/PD 2022), Barcelona, Spain, March 15-20, 2022 (oral presentation)

- H. Cho, “Air particulate pollutant inducing neurodegenerative inflammation,” 3rd International Webinar on Dementia and Alzheimer Rehabilitation, Feb. 26, 2022 (oral presentation, plenary talk)


2021

39. Y.J. Kang, H.-Y. Tan, C.Y. Lee, H. Cho “An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models,” Advanced Science 2021, 8:2101251 (frontispiece cover imaged)

38. V.T.A. Tran, Y.J. Kang, H-K Kim, H-R Kim, H. Cho “Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform,” International Journal of Molecular Science 2021, 22:6925

37. Y.J. Kang, H. Cho “Human brain organoids in Alzheimer’s Disease,” Journal of Organoid 2021, 1:1e5

36. A. Bittner, F. Gosselet, E. Sévin, L. Dehouck, A. Ducray, V. Gaschen, M.H. Stoffel, H. Cho, M. Mevissen “Time-dependent internalization of polymer-coated nanoparticles in brain endothelial cells and morphological and functional effects on the blood-brain barrier,” International Journal of Molecular Science 2021, 22:1657

35. H.-Y. Tan, H. Cho*, Luke P. Lee* (*:co-corresponding), “Human mini-brain models,” Nature Biomedical Engineering 2021, 4:11


- Y.N. Diep, H.Y. Ko, W. Lim, S. Park, M.J. Yun, H. Cho, “Glial Scar Causing Drug Resistance and Inhibiting Glioblastoma Growth in a 3D Human Glioblastoma Microenvironment,” the Society for Neuroscience’s annual meeting 2021 (Neuroscience 2021), Chicago, IL, USA, Nov. 11, 2021

- V.T.A. Tran, Y.J. Kang, H-K Kim, H-R Kim, H. Cho, “Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform,” The 5th International Webinar on Global Advanced Nursing, Scientific Meditech, Nov. 19-20, 2021 (oral presentation)


2020

34. Y.J. Kang, Y.N. Diep, M. Tran, H. Cho “Therapeutic Targeting Strategies for Early-To Late-Staged Alzheimer’s Disease,” International Journal of Molecular Science 2020, 21:9591

33. H. Chun, H. Im, Y.J. Kang, Y. Kim, J.H. Shin, W. Won, J. Lim, Y. Ju, Y.M. Park, S. Kim, S.E. Lee, J. Lee, J. Woo, Y. Hwang, H. Cho, S. Jo, J.-H. Park, D. Kim, D.Y. Kim, J.-S. Seo, B.J. Gwag, Y.S. Kim, K.D. Park, B.-K. Kaang, H. Cho, H. Ryu*, C.J. Lee*, “Severe reactive astrocytes precipitate the hallmarks of Alzheimer’s disease via H2O2,” Nature Neuroscience 2020, 23:9

32. A. McQuade, Y.J. Kang, J. Hasselmann, A. Jairaman, A. Sotelo, S.K. Shabestari, M. Coburn, J.P. Chadarevian, G. Fote, C.H. Tu, E. Danhash, J. Silva, E. Martinez, C. Cotman, G.A. Prieto, L.M. Thompson, J.S. Steffan, I. Smith, H. Davtyan, M. Cahalan, H. Cho, M. Blurton-Jones, “Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease,” Nature Communications 2020, 11:5320


- V.T.A. Tran, Y.J. Kang, H-R Kim, H. Cho, “Assessment of neurodegenerative microgliosis induced by oral pathogenic bacteria,” Cold Spring Harbor Lab, Neurodegenerative Diseases: Biology & Therapeutics, Dec. 2-4, 2020

- M. Bae, Y.J. Kang, H-G Yi, T-H Ngo, T-M Tran, J.J. Kim, J. Jang, D-W Cho, H. Cho, “Provision of Physiological Cerebral Environment by Using Brain Decellularized Extracellular Matrix,” the Biomedical Engineering Society Virtual Annual Meeting (BMES2020), Oct. 14-17, 2020


2019

31. J. Park, S. H. Baik, I. Mook-Jung, D. Irimia, H. Cho, “Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil,” Frontiers in Immunology 2019, 10:2231

30. J. Shin, M.H. Hwang, S. Back, H.G. Nam, C.M. Yoo, J.H. Park, H.G. Son, J.W. Lee, H. Lim, K.H. Lee, H. Moon, J. Kim, H. Cho, H. Choi “Electrical impulse effects on degenerative human annulus fibrosus model to reduce disc pain using micro-electrical impulse-on-a-chip,” Scientific Reports 2019, 9:5827


- W. Groves, K. Rubio, I. Wetzel, H. Cho, “Co-axial extrusion of multicellular blood-brain barrier,” TERMIS-AM Annual Conference, Orlando, FL, USA, Dec. 2-5, 2019

- W. Groves, M. Bae, Y.J. Kang, J. Jang, H-G Yi, D-W Cho, H. Cho, “Development of Physiologically relevant Human Brain Models by Using Brain Decellularized Extracellular Matrix,” the Biomedical Engineering Society Annual Meeting (BMES2019), Philadelphia, PA, USA, Oct. 16-19, 2019

- Y.J. Kang, H. Chun, C.J. Lee, H. Cho, “Neurodegenerative microglial activation exacerbated by astrocytes-driven oxidative stress and proinflammation in a human Alzheimer’s disease brain model,” the Society for Neuroscience’s 47th annual meeting (Neuroscience 2019), Chicago, IL, USA, Oct. 19-23, 2019

- G. Ambrin, B.R. Singh, H. Cho, “Assessment of Adverse Neurotoxicity of BoNT/A by Using an Engineered Human Brain Model,” the Society for Neuroscience’s 47th annual meeting (Neuroscience 2019), Chicago, IL, USA, Oct. 19-23, 2019, (oral presentation, HOT 100s out of 14,000 abstracts)

- H. Chun, Y. Kim, Y.J. Kang, H. Im, J.H. Shin, Y. Ju, W. Won, Y.M. Park, J. Lim, J.A. Lee, J.W. Oo, Y. Hwang, S. Jo, I.W. Etzel, J-H Park, D. Kim, D.Y. Kim, B.J. Gwag, Y. Kim, K.D. Park, B-K Kaag, H. Cho, H. Ryu, C.J. Lee, “Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via excessive H2O2-production,” the 10th World Congress of Neuroscience by International Brain Research Organization (IBRO 2019), Daegu, Korea, Sept. 21-25, 2019

- Y. Kang, H. Chun, C.J. Lee, H. Cho, “Neurodegenerative Astrogliosis Mediated by Oxidative Stress in Alzheimer's Diseased Human Model,”the 10th World Congress of Neuroscience by International Brain Research Organization (IBRO 2019), Daegu, Korea, Sept. 21-25, 2019


2018

29. Y.J. Kang, E.G. Cutler, H. Cho, “Therapeutic Nanoplatforms and Delivery Strategies for Neurological Disorders,” Nano Convergence 2018, 5:35

28. L.H. Chong, H. Li, I. Wetzel, H. Cho, Y.C. Toh, “A liver-immune coculture array for predicting systemic drug-induced skin sensitization,” Lab on a Chip 2018, 21:3239-3250

27. H. Chun, I. Marriott, C.J. Lee, H. Cho, “Elucidating the Interactive Roles of Glia in Alzheimer’s Disease Using Established and Newly Developed Experimental Models,” Frontiers in Neurology 2018, 9:797

26. J. Park, I. Wetzel, I. Marriott, D. Dréau, C. D’Avanzo, D.Y. Kim, R.E. Tanzi, H. Cho, “A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease,” Nature Neuroscience 2018, 21:941-951

25. X. Du, W. Li, G. Du, H. Cho, M. Yu, Q. Fang, L.P. Lee, J. Fang, “Droplet Array-Based 3D Coculture System for High-Throughput Tumor Angiogenesis Assay,” Analytical Chemistry 2018, 90 (5):3253–3261

24. J. Park, I. Wetzel, D. Dréau, H. Cho, “3D Miniaturization of Human Organs for Drug Discovery,” Advanced Healthcare Materials 2018, 7:1700551 (front cover imaged)


- L.H. Chong, H. Li, I. Wetzel, H. Cho, Y.-C. Toh, “Liver-Immune co-culture array predicts drug-metabolism induced skin sensitization” 22ndInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2018), Kaohsiung, Taiwan, Nov. 11-15, 2018, (oral presentation)

- J. Park, I. Wetzel, I. Marriott, D. Dréau, D.Y. Kim, R.E. Tanzi, H. Cho, “Reconstructed neurotoxic microglial activation triggered by reactive astrocytes in a 3d organotypic human Alzheimer’s disease brain model,” the Society for Neuroscience’s 46th annual meeting (Neuroscience 2018), San Diego, CA, USA, Nov. 3-7, 2018 (oral presentation, selected as a Neuroscience 2018 Hot Topic)

- I. Wetzel, H. Cho “Single-Step Co-Axial Extrusion (SS-CAE) for Construction of Human Blood-Brain Barrier Model in 3D,” the Biomedical Engineering Society Annual Meeting (BMES2018), Atlanta, GA, USA, Oct. 17-20, 2018

- G. Ambrin, S. Cai, B.R. Singh, H. Cho “Engineering Multicellular Human Brain Model and Assessing Adverse Toxicity of BoNT/A Leading to Synaptic Impairment in Alzheimer’s Disease,” the Biomedical Engineering Society Annual Meeting (BMES2018), Atlanta, GA, USA, Oct. 17-20, 2018

- J. Park, I. Wetzel, S. H. Baik, I. Mook-Jung, D. Irimia, H. Cho, “The roles of neutrophils in the CNS mediated by reactive microglia in AD,” Gordon Research Conference: Barriers of the CNS Gordon Research Conference, New London, NH, USA, June 17-22, 2018


2017~2016

23. M.H. Hwang, D.H. Cho, S.M. Baek, J.W. Lee, J.H. Park, C. M. Yoo, J.H. Shin, H.G. Nam, H.G. Son, H.J. Lim, H. Cho, H.J. Moon, J.H. Kim, J. K. Lee, H. Choi, “Spine-on-a-chip: Human annulus fibrosus degeneration model for simulating the severity of intervertebral disc degeneration,” Biomicrofluidics 2017, 11:064107


- J. Park, I. Wetzel, H. Cho, “Mimicry of Neuroinflammatory Environment in Alzheimer’s Disease and Discovery of Microglial Modulation in Neutrophil Recruitment to Central Nervous System,” TERMIS-AM annual conference, Charlotte, NC, USA, Dec. 3-6, 2017 (oral presentation)

- J. Park, Ram Ganapathi, H. Cho, “Cooperative role of glioma and microglia migration in tumor mimicking microenvironment through the paracrine PAI-1/IL6 signaling,” Annual Symposium: Charlotte Biomedical Science and Engineering, Charlotte, NC, USA, May 5, 2017 (oral presentation)

- J. Park, D. Dréau, D. Y. Kim, R. E. Tanzi, H. Cho, “Neuron-Glia Interactions in 3D Organotypic Human Alzheimer’s Disease Brain Model,” Gordon Research Conference: Glial Biology: Functional Interactions Among Glia & Neurons, Ventura, CA, USA, Mar. 5-10, 2017

- J. Park, D.Y. Kim, R.E. Tanzi, H. Cho, “Microglial Activation and Neuronal Loss on Recapitulated 3D Human 3D Alzheimer’s Disease Brain Model,” the Society for Neuroscience’s 44th annual meeting (Neuroscience 2016), San Diego, CA, USA, Nov. 12-16, 2016


2014~2010 @ Harvard Medical School

22. E. Reátegui, A. Khankel, B. Jalali, E. Wong, H. Cho, C. N. Serhan, J. Dalli, H. Elliot, D. Irimia, “Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming,” Nature Biomedical Engineering 2017, 1:0094 (cover imaged)

21. K.W. Bong, J.J. Kim, H. Cho, E. Lim, P. Doyle, D. Irimia, “Synthesis of Cell-Adhesive Anisotropic Multifunctional Particles by Stop Flow Lithography and Streptavidin-Biotin Interactions,” Langmuir 2015, 8:13165-13171

20. H. Cho, J.H. Seo, K.H.K. Wong, Y. Terasaki, J. Park, K. Bong, K. Arai, E.H. Lo, D. Irimia, “Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology,” Scientific Reports 2015, 5:15222

19. S. Takedaa, S. Wegmanna, H. Cho, S.L. DeVosa, C. Comminsa, A.D. Roea, S.B. Nichollsa, G.A. Carlsonc, R. Pitstickc, C.K. Nobuharaa, I. Costantinoa, M.P. Froscha, D.J. Müllerd, D. Irimiab, B.T. Hyman, “Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau species derived from tau-transgenic mouse and human Alzheimer's disease brain,” Nature Communications 2015, 6:4890

18. Y. Hori, S. Takeda, H. Cho, S. Wegmann, T. M. Shoup, K. Takahashi, D. Irimia, D.R. Elmaleh, B.T. Hyman, E. Hudry, “A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease” Journal of Biological Chemistry 2015, 290:1966-1978

17. H. Cho*, B. Hamza* (*equal contribution), E.A. Wong, D. Irimia, “On-demand, Competing Gradient Arrays for Neutrophil Chemotaxis,” Lab on a Chip 2014, 14:972-978

16. S.H. Baik, M.-Y. Cha, Y.-M. Hyun, H. Cho, B. Hamza, D.K. Kim, S.-H. Han, H. Choi, K.H. Kim, M. Moon, J. Lee, M. Kim, D. Irimia, I. M.-J., “Migration of Neutrophils Targeting Amyloid Plaques in Alzheimer’s Disease Mouse Model,” Neurobiology of Aging 2014, 35: 1286-1292

15. B. Hamza, S. Patel, E. Wong, H. Cho, J. Martel, D. Irimia, “Retrotaxis of Human Neutrophils during Mechanical Confinement inside Microfluidic Channels,” Integrative Biology 2014, 6:175-183

14. H. Cho, T. Hashimoto, E.A. Wong, L. Zhao, Y. Hori, L.B, Wood, K.M. Haigis, B.T. Hyman, D. Irimia, “Microfluidic Chemotaxis Platform for Differentiating the Distinct Roles of Soluble and Bound Amyloid-β on Microglial Accumulation,” Scientific Reports 2013; 3:1823


- E. Reátegui, A. Khankel, B. Jalali, E. Wong, H. Cho, C. N. Serhan, J. Dalli, H. Elliot, D. Irimia “Inter-Cellular Signals during Human Neutrophil Swarming,” the Biomedical Engineering Society Annual Meeting (BMES2016), Minneapolis, WA, USA, Oct. 5-8, 2016

- H. Cho, S. H. Baik, I. Mook-Jung, D. Irimia, “Neutrophil Recruitment is Mediated by Soluble Factors from Microglia during Alzheimer’s Disease,” Gordon Research Conference: Glial Cells in Health and Disease, Ventura, CA, USA, Mar. 1-6, 2015

- H. Cho, S. H. Baik, I. Mook-Jung, D. Irimia, “Neutrophil Recruitment is Mediated by Soluble Factors from Microglia during Alzheimer’s Disease,” the Society for Neuroscience’s 44th annual meeting (Neuroscience 2014), Washington, DC, USA, Nov. 15-19, 2014

- H. Cho, J. H. Seo, K. Wong, K. Bong, Yasukazu Terasaki, K. Arai, E. H. Lo, D. Irimia, “A Tube-shaped in vitro Blood-Brain-Barrier Model in Planar Microfluidics,” the Society for Neuroscience’s 43rd annual meeting (Neuroscience 2013), San Diego, CA, USA, Nov. 9-13, 2013

- H. Cho, J. H. Seo, K. Wong, K. Bong, K. Arai, E. H. Lo, D. Irimia, “A Tube-shaped in vitro Blood-Brain-Barrier Model in Planar Microfluidics,” the Biomedical Engineering Society Annual Meeting (BMES2013), Seattle, WA, USA, Sep. 25-28, 2013 (oral presentation)

- H. Cho, B. Hamza, E. Wong, D. Irimia, “Microfluidic Platform for On-Demand, Competitive, Large-Scale Chemotaxis Assays of Neutrophils,”the Biomedical Engineering Society Annual Meeting (BMES2013), Seattle, WA, USA, Sep. 25-28, 2013 (oral presentation)

- H. Cho, T. Hashimoto, E. Wong, B.T. Hyman, D. Irimia, “Distinct Roles of Amyloid Beta on Microglial Accumulation in Alzheimer’s Disease,”the Biomedical Engineering Society Annual Meeting (BMES2012), Atlanta, GA, USA, Oct. 24-27, 2012 (oral presentation)

- H. Cho, T. Hashimoto, E. Wong, B.T. Hyman, D. Irimia, “Ex vivo Alzheimer's Disease Model Characterizing Accumulation of Microglia Cells Recruited by Soluble Amyloid Beta and Localized by Surface-Bound Amyloid Beta Fibrils,” the Society for Neuroscience’s 42nd annual meeting (Neuroscience 2012), New Orleans, LA, USA, Oct. 13-17, 2012

- H. Cho, E. Hudrey, M. Toner, B.T. Hyman, D. Irimia, “Migration of Microglia Is Modulated by Amyloid Beta during the Progression of Alzheimer Disease,” the Biomedical Engineering Society Annual Meeting, (BMES2011), Hartford, MA, USA, Oct. 12-15, 2011 (oral presentation)


2010~2005 @ UC Berkeley

13. H. Cho, E. -C. Yeh, R. Sinha, T.A. Laurence, J.P. Bearinger, L.P. Lee, “Single­Step Nanoplasmonic VEGF165 Aptasensor for Cancer Diagnosis,” ACS Nano 2012; 6:7607-7614

12. C.V. Pagba, S.M. Lane, H. Cho, S. Wachsmann-Hogiu, “Direct Detection of Aptamer-Thrombin Binding via Surface-Enhanced Raman Spectroscopy,” Journal of Biomedical Optics 2010; 15:0470061-0470068

11. T. Kokalj*, H. Cho* (*equal contribution), M. Jenko, L.P. Lee, “Biologically-Inspired Porous Cooling Membrane Using Arrayed-Droplets Evaporation,” Applied Physics Letters 2010; 96:163703-163705

10. H. Cho, B. Lee, G.L. Liu, A. Agarwal, L.P. Lee, “Label Free and Highly Sensitive Biomolecular Detection Using SERS and Electrokinetic Preconcentration,” Lab on a Chip 2009; 9:3360-3363

9. D. Choi, T. Kang, H. Cho, Y. Choi, L.P. Lee, “Additional Amplifications of SERS via Optofluidic CD-Based Platform,” Lab on a Chip 2009; 9:239-243

8. H. Cho, B.R. Baker, S. Wachsmann-Hogiu, C.V. Pagba, T.A. Laurence, S.M. Lane, L.P. Lee, J.B.H. Tok, “Aptamer-Based SERRS Sensor for Thrombin Detection,” Nano Letters 2008; 8:4386–4390


- H. Cho, E.C. Yeh, R. Sinha, L.P. Lee, “Aptamer-Based Nanoplasmonic VEGF165 Sensor for Breast Cancer Diagnostics,” the Biomedical Engineering Society Annual Meeting, (BMES2010), Austin, TX, USA, Oct. 6-9, 2010 (oral presentation)

- H. Cho, A. Kimteng, L.P. Lee, “Bidirectional Fluidic Diode,” 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2010) Groningen, the Netherlands, Oct. 3-7, 2010, (oral presentation)

- T. Kokalj, H. Cho, M. Jenko, L.P. Lee, “Skin-Inspired Cooling Surface,” Lab-on-a-chip European Congress, Dublin, Ireland, May 25-26, 2010

- H. Cho, R. Sinha, L.P. Lee, “Real-Time and Label-Free Aptasensor of VEGF for Cancer Diagnostics,” AACR 101st Annual Meeting, Washington, DC, USA, April 17-21, 2010, AACR highlighted

- C.V. Pagba, H. Cho, S. Lane, S. Wachsmann-Hogiu, “Aptamer-based label-free direct detection of thrombin using SERS,” The 238th ACS National Meeting, Washington, DC, USA, August 16 – 20, 2009; 237:491-491

- H. Cho, Y. Zhang, B. Lee, A. Kimteng, J.P. Beringer, B.R. Baker, T.A. Laurence, S.M. Lane, L.P. Lee, “Integrated Microfluidic Platform with Nanoplasmonic Aptasensor for On-Chip Lable-Free VEGF Detection in Dynamic Tumor Microenvironment,” 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2009), Jeju, Korea, November 1-5, 2009; 1482-1484

- H. Cho, Y. Zhang, B.R. Baker, L.P. Lee, “Integrated Microfluidic Platform with Surface-Plasmonic Aptasensor for On-chip Label-free Detection of Cancer Markers from Cells,” 10th Annual UC Systemwide Bioengineering Symposium, Merced, CA, USA, June 19-21, 2009 (oral presentation)

- H. Cho, B.R. Baker, S. Wachsmann-Hogiu, C. Pagba, T. Laurence, S.M. Lane, L.P. Lee, J.B.H. Tok, “Detection of Thrombin by Aptamer-Based Surface Enhanced Resonance Raman Spectroscopy,” 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2008), San Diego, CA, USA, October 12-16, 2008:290-292

- D. Choi, T. Kang, H. Cho, Y. Choi, L.P. Lee, “SERS Signal Amplification via Biofluidic-Adsorption Preconcentration in Optofluidic CD Platform,” 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2008), San Diego, CA, USA, October 12-16, 2008:964-966

- H. Cho, Y.T. Long, B. Lee, L.P. Lee, “Electrokinetic SERS Signal Amplification for Label-free Biomolecular Detection,” 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2007), Paris, France, October 7-11, 2007; 2:1182-1184 (oral presentation)

- H. Cho, Y.T. Long, L.P. Lee, “Study on Biomolecules by Electrokinetic Concentration-Based SERS Amplification,” Biophysical Society's 51st Annual Meeting, Baltimore, Maryland, USA, March 3-7, 2007

- H. Cho, L.P. Lee, “A Novel Integrated Microfluidic SERS-CD with High-Throughput Centrifugal Cell Trapping Array for Quantitative Biomedicine," 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2006), Tokyo, Japan, Nov. 5 - 9, 2006; 1:642

- H. Cho, J. See, L.P. Lee, "A Novel Integrated Centrifugal Cell Trapping SERS-CD Platform for Quantitative Cell Analysis," the Biomedical Engineering Society Annual Meeting (BMES2006), Chicago, IL, USA, Oct. 11-14, 2006

- H. Cho, B. Kim, L.P. Lee, “Tunable Surface-Enhanced Raman Scattering Probes for Single Biomolecular Detections,” Biophysical Society's 50th Annual Meeting, Salt Lake City, UT, USA, February 18-22, 2006


2005~2003 @ KIST

7. B.C. Chang, S.H. Lim, H. Cho, S. Lee, J.H. Lee, Y.S. Hong, Y.N. Youn, Y.H. Park, “Preclinical Test of an Electro-Mechanical Implantable Left Ventricular Assist System,” Korean Circulation Journal 2008; 38:7-11

6. H. Cho, H.Y. Kim, J.Y. Kang, T.S. Kim, “How the Capillary Burst Microvalve Works,” Journal of Colloid and Interface Science 2007; 306:379-385

5. J.H. Kim, H.J. Shin, H.J. Cho, S.M. Kwak, H. Cho, T.S. Kim, J.Y. Kang, E.G. Yang, “A Microfluidic Protease Activity Assay Based on the Detection of Fluorescence Polarization,” Analytica Chimica Acta 2006; 577:171-177

4. J.H. Lee, J.M. Jang, H. Cho, K.C. Han, T.S. Kim, J.Y. Kang, E.G. Yang, “Design and Characterization of Microfluidic Analysis System for RNA-Aminoglycoside Interactions,” Key Engineering Materials 2005; 277-279:90-95

3. H. Cho, H.-Y. Kim, J.-Y. Kang, S.-M. Kwak, T.-S. Kim, “Analysis and Evalution of Capillary Passive Valves in Microfluidic Systems Using a Centrifugal Force,” KIEE Int. Transact. EA 2004; 4:155-159


- H. Cho, H.Y. Kim, J.Y. Kang, S.M. Park, T.S. Kim, "Modeling of Capillary Passive Valve and Fabrication Using SU-8," the 6th Conference of HARMST, Gyeongju, Korea, June 6-13, 2005; 1: PD07

- H. Cho, J.Y. Kang, S.M. Kwak, K. Hwang, J. Min, J. Lee, D. Yoon, T.S. Kim, "Integration of PDMS Microfluidic Channel with Silicon-Based Electromechanical Cantilever Sensor on a CD Chip," IEEE 18th Int. Conf. on MEMS, Miami, FL, USA, March 2005; 18:698-701

- J.Y. Kang, H. Cho, S.M. Kwak, D.S. Yoon, T.S. Kim, "Novel Particle Separation Using Spiral Channel and Centrifugal Force for Plasma Preparation from Whole Blood," the 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2004), Malmo, Sweden, Sep. 26-30, 2004; 8:614-616

- H. Cho, H.Y. Kim, J.Y. Kang, T.S. Kim, "Capillary Passive Valve in Microfluidic System," the 7th Conference on Nanotech, Boston, MA, USA, March 7-11, 2004; 7:263-266

- J.H. Lee, J.M. Jang, H. Cho, T. Kim, E.G. Yang, "Development of High-Throughput Screening Systems for RNA Targets Using Microfluidic Chips," International women's conference on BIEN-technology, Daejeon, Korea, Nov. 13-16, 2003:218


2002~1999 @ BiomedLab

2. W.G. Kim, W.Y. Lee, B.H. Lee, H. Cho, “A Simplified Cardiopulmonary Bypass Technique for Animal Experiments on Implantable Ventricular Assist Devices,” International Journal of Artificial Organs 2002; 25:147-50

1. H. Cho, W.G. Kim, W.Y. Lee, S.M. Kwak, S.S. Kim, J.K. Kim, J.T. Kim, M.H. Ryu, E.S. Ryu, K.C. Moon, B.S. Su, H.J. Yu, G.J. Yoon, H.J. Jeong, J.S. Choi, S.J. Hwang, J.W. Kim, B.G. Min, “Development and Evaluation of a Novel Electro-Mechanical Implantable Ventricular Assist System,” Journal of Biomedical Engineering Research 2001; 22:349-358


- H. Cho, B.C. Chang, S. Kim, D. Min, G.J. Yoon, J. Kim, "Further Development of the Cylindrical Cam Type IVAD as a Clinical Model," ASAIO (American Society of Artificial Organs) J. 2002; 48:2:162

- S.S. Cheon, H. Cho, M.H. Ryu, J. Kim, "Development of a Pump Output Estimation Algorithm Using Motor Current for a Pulsatile Implantable IVAD," ASAIO J 2002; 48:2:161

- S.H. Lim, B.C. Chang, Y.S. Hong, H. Cho, "Preliminary Result of Thrombosis and Hemolysis in Biomedlab Implantable Ventricular Assist Device", ASAIO J 2002; 48:2:140

- H. Cho, W.G. Kim, J.S. Choi, B.S. Soo, E.S. Ryu, G.J. Yoon, M.H. Ryu, J. Kim, B.G. Min, "Development of Implantable Ventricular Assist System with a Cylindrical Cam," ASAIO J 2001; 47:2:145

- M.H. Ryu, J.S. Choi, H. Cho, G.J. Yoon, J. Kim, B.G. Min, "An Automatic Driving Method for a Pulsatile Implantable Ventricular Assist Device", ASAIO J 2001; 47:2:142

- H. Cho, W. Kim, G.J. Yoon, M.H. Ryu, B.S. Soo, J. Kim, "Development of an implantable ventricular assist system with a double cylindrical cam," Int. J. Artificial Organs 2001; 25:2:790

- H. Cho, W.W. Choi, B.S. Soo, G.J. Yoon, H.J. Yu, J.K. Kim, M.S. Kim, M.S. Park, S.M. Kwak, J. Kim, B.G. Min, "Development of a New Implantable Ventricular Assist Device," ASAIO J 2000; 46:2:204

- H. Cho, K.S. Om, H.S. Lee, J.H. Chung, B.G. Min, "Flow Modeling Around Prosthetic Heart Valve Using Pressure Difference," the 4th Asia-pacific Conference on medical & biological conference, Seoul, Korea, Sep. 12-15, 1999; 4:251 (oral presentation)

- K.S. Om, J.M. Ahn, C.Y. Park, G.J. Yun, H. Cho, J. Kim, Y.H. Jo, W.E. Kim, Y.N. Park, J.S. Choi, J.W. Park, S.W. Choi, W.K. Kim, and B.G. Min, "The Automatic Control of the Moving-Actuator Type Totally-Implantable Artificial Heart Using the Motor Current," the 4th Asia-pacific Conference on medical & biological engineering, Seoul, Korea, Sep. 12-15, 1999; 4:239



Patents

  • Composition for culturing brain immune cells having Matrigel, and preparation method thereof, KOREA, Pat. No. 10-2022-0029550, Registration date: 2022.03.08
  • Composition for differentiating human neural progenitor cell and culturing neuron having porcine-brain derived extracellular matrix, and Preparation method thereof, KOREA, Pat. No. 10-2022-0029549, Registration date: 2022.03.08
  • 3D high aspect-ratio, ultra-fine tissue chips and manufacturing method thereof, KOREA, Pat. No. 10-2021-0103730, Registration date: 2021.08.06
  • Mimicry of neuroinflammatory microenvironments and methods of use and manufacturing thereof, USA, APP. No. 15/670354, Pub. Date: 2017.08.07
  • Microfluidic platform and related methods and systems, USA, Pub. No. 2010/0136551, Pub. date: 2010.06.03
  • Aptamer based sensors and related methods and systems, USA, Pub. No. 2010/0105053, Pub. date: 2010.04.29
  • Method and apparatus for measuring fluorescence polarization in lab-on-a-chip, USA, Pat. No. 7427509, Registration date: 2008.09.23
  • Implantable left ventricular assist device with cylindrical cam, USA, Pat. No. 7105022, Registration date: 2006.09.12
  • Parallel mechanism for multi-machining type machining center, USA, Pat. No. 6135683, Registration date: 2000.10.24
  • Composite process type machining center and parallel mechanism structure thereof, Japan, Pub. No. 11-207549, Pub. date: 1999.03.08
  • Fluorescence polarization measurement method and apparatus for lab-on-a-chip, KOREA, Pat. No. 10-0822810-0000, Registration date: 2008.04.10
  • RNA conjugated medicines search method using micro fluid control fluorescence detection system, KOREA, Pat. No. 10-0782046-0000, Registration date: 2007.11.28
  • Cell dispersion micro fluidics chip and patch clamping lab on a chip using the same, KOREA, Pat. No. 10-0749908-0000, Registration date: 2007.08.09
  • An implantable ventricular assist device with cylindrical cam, KOREA, Pat. No. 10-0693392-0000, Registration date: 2007.03.05
  • Microfluidic chip for high-throughput distributing a cell and patch clamping lab-on-a-chip using the same, KOREA, Pat. No. 10-0644862-0000, Registration date: 2006.11.03
  • Minute particle separation method and apparatus using the centrifugal force and microfluidic channel, KOREA, Pat. No. 10-0618121-0000, Registration date: 2006.08.23
  • The micro fluidics supply oil the design method and biomaterial measuring device using the same, KOREA, Pat. No. 10-0608999-0000, Registration date: 2006.07.27
  • Implantable pulse type left ventricular assist device, KOREA, Pat. No. 10-0339822-0000, Registration date: 2002.05.24
  • Overdriving complex process type machining center, KOREA, Pat. No. 10-0266904-0000, Registration date: 2000.06.28
  • Complex process type machining center, KOREA, Pat. No. 10-0241701-0000, Registration date: 1999.11.04
  • The parallel mechanism structure for controlling the position and posture on 3D, KOREA, Pat. No. 10-0237553-0000, Registration date: 1999.10.08
  • The parallel mechanism structure for controlling the position and posture on 3D, KOREA, Pat. No. 10-0237552-0000, Registration date: 1999.10.08